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Wednesday, July 31, 2019

Do new dependency theories overcome the weaknesses of classical dependency theories?

IntroductionOver the century’s, economic development theorist have put forward various models for explaining the â€Å"underdeveloped-ness† of countries in the Third World. However, with sociological theory comes criticisms and despite lasting a great deal of time in the framework of the international sphere, classical dependency has been subjected to a barrage of criticism on theoretical, empirical, methodological, and stylistic grounds. In this essay, it is my aim to analyse the criticism put forwards while simultaneously determining whether or not the modification by new dependency theorists have overcome these flaws.Before doing so we must firstly acquaint ourselves with the origins of the dependency theory, first formulated in the late 1950s under the guidance of the Director of the United Nations Economic Commission for Latin America, Raul Prebisch. The second part of this essay will provide an analytic account of Paul Baran and Andre Gunder Frank’s classic al studies of dependency theory, looking at their general perspectives and adaptation to Marxism.Once this has been achieve, the third and final part of this essay aims to draw out the criticism that have been put forward on classical dependency studies while looking at new dependency theorist; Fernando Henrique Cardoso, Stephan M. Haggard and Thomas B. Gold perspectives. This will allow me to conclude how sophisticated new dependency studies are in overcoming the flaws of the classical dependency studies. Origins of Dependency Theories Given the many interpretations given to dependency, how can one capture the concept of dependency in a concise manner?Dos Santos, defines it as â€Å"a historical condition that shapes a certain structure of the world economy such that it favours some countries to the detriment of others, and limits the development possibilities of the subordinate economies†. (SO, A, Y. 1990: 99) Whereas liberals (mainstream economists) define underdevelopment as a condition in which countries find themselves in, depedentistas see it as a process in which less developed nations are trapped because of the relationship between the developed and underdeveloped countries in the world economy. (SANCHEZ, O.  2003)However, it can be agreed that dependency theory is not a socioeconomic relation that just â€Å"occurs†, it is developed historically through capitalism’s power-relations between the first world and the third world. In order to understand dependency theory, we first need to place the model in historical context by examining its origins. Emerging in the late 1940’s against the development theory of modernization which examined development from the point of view of the United States and other Western Countries, The Dependency Theory took the approach of viewing development from a Third World perspective.According to Blomsorm and Hettne, the dependency theory represents the â€Å"voices from the periphery†. (Blomsorm, M, Hettne, B. 1984) Dependency theory arose out of central and south America in the 1960s and 1970s, but was part of a larger movement that was asking a lot of questions about international relations at the time. One of those questions was â€Å"why are so many countries not developing? † The traditional answer to this question was that these countries are not perusing the right economic policies or the governments are authoritarian or corrupt.However, dependency theorists wanted to find out if that was all there was to it, which lead them to argue that countries were not developing around the world due to international division of labour, class distinction and global capitalism. The diagram above (Wikimedia commons, 2008) is a clear example of what dependency theorist meant when they argue that there are a number of different kinds of states in the world which all form a different funtion in the world’s economy. First you have the core states are the most richest and powerful (e.g Europe and North America).These states dominate in terms of industry and technology and as a result the semi-periphey and periphery states (e. g Latin America and South Africa), who are characterised by resource extraction economy, argiculture production and providing cheap labour, serve the economic intrest of the richest countires. Dependency theory became popular as a criticism of modernization theory (also known as development theory) which seemed to be failing due to the continued widespread poverty of large parts of the world.This may be because modernisation theory only offers an â€Å"internal† explanation of Third world development. For example, it assumes that there is something wrong inside Third world countries- such as traditional culture, overpopulation, little investment, or lack of achievement motivation- and this is why Third world countries are backward and stagnant. (So, A, Y. 1990: 92) The theory believes in order for third world countries to reach modernity they need to look up to western countries as mentors and follow western paths of development.However, dependency theorists argue that this is impossible to do so because of colonialism. â€Å"The colonial experience has totally restructured Third world countries and has drastically altered their paths of development† (So, A, Y. 1990. :96) Looking back at liberal reformer Prebisch and the ECLA strategy of protectionism and industrialization, he believed, in order to put an end to all problems of development, poorer countries should embark on programs of import substitution so that they need not purchase the manufactured products from the richer countries.The poorer countries would still sell their primary products on the world market, but their foreign exchange reserves would not be used to purchase their manufactures from abroad. (Larrain, J, 1989:110) However, this was not as straight forward as anticipated, because if a poorer nation makes any a ttempt to resist against the power of the rich nations they may have to face military force or economic sanctions.â€Å"Developed nations actively keep developing nations in a subservient position, often through economic force by instituting sanctions, or by proscribing free trade policies attached to loans granted by the World Bank or International Monetary Fund†. (WiseGeek, 2003) Despite the failure of Prebisch international trade theory, it is undoubtable that it provided the dependency theory with the support that it needed, and showed some semblance of what dependence means in this type of economic system. (Moses, D, 2012)In a nutshell, Development and Underdevelopment are two sides of the same coin. Wealthy nations of the world need a peripheral group of poorer states in order to remain wealthy. Using a variety of political economic interventions as well as media, education systems and interventional sporting events wealthy nations control poorer nations, making them de pendent. And it is in their best interest to keep the poorer nations poor by using Ha-Joon Chang metaphor â€Å"kicking the developing ladder away† so that they can continue to steal the poor’s natural wealth and exploit their workers.Latin America was asked to produce food, raw materials for the great industrial center, and in return, Latin America would receive industrial goods from these centers. (So, A, Y. 1990:93) Classical Dependency Theory In this next section we will examine Neo-Marxist theorist’s Paul Baran (1910–1964) and Andre Gunder Frank’s (1929–2005) who developed dependency theory from Marxian analysis.â€Å"The dependency theory is rooted in a Marxism analysis of the global economy and as a direct challenge to the free market economic policies of the post-War era† (Ferraro, V, 2008) In The Communist Manifesto, Marx argued within the capitalist economy the bourgeoisie mercilessly exploited the proletariat. He recognised that the work carried out by the proletariat created great wealth for the capitalist. The products created in the factory (the material outcome of the workers' labour) were sold for more than the value of the labour itself i. e. more than the workers' wages.Like Karl Marx (1818–1883), Baran and Frank argued a similar exploitative system of stratification between countries. Usage of Marxist ideology can be seen as strength of the dependency theory as led the way to other neo-Marxist investigations of the linkage and possible reconciliation between Dependency Theory and Marxism. Paul A Baran Baran is the first author within the theory of imperialism who studies the class structures and economic processes of underdeveloped countries, but more importantly, he was the first Marxist author who puts in doubt the homogeneous conception of world capitalism.  (Larrain, J, 1989:80)Baran believed imperialism had penetrated underdeveloped countries, destroying earlier social formations and distorting their subsequent development, creating lasting conditions of dependency. Underdeveloped countries were systematically subordinated to the developed countries in the international division of labour. However, Baran was not the first to make such arguments. Traces of such views of imperialism can be found in Marxism.â€Å"if it were not for the distorting effects of imperialism, the country that is more developed industrially would have shown to the less developed the image of its own future† (Foster, J, 2007) Baran’s Political Economy of Growth argued that Third world countries were characterized by small industrial sectors and large agricultural sectors, which was not immensely profitable on world a scale. He emphasized class relations and their impact on utilization of economic surplus, as well as the distribution of power as primary barriers which prevented development.He espoused that internal conditions were the source of the major problems in under developed countries, and recommended state intervention to promote nationally controlled industrialization as a precondition for evolution of other industrial sectors. (TheDevelopmentStudent, 2010) Baran’s uses his study of India as an example of a country which would have developed much better had it not been for the surplus torn from it by Britain. In his study he traced how British colonialism contributed to the underdevelopment of India through plundering, deindustrialisation, and the uprooting of the local society.  (So, A, Y. 1990:111)Although, Baran agrees with Marx that one should not idealise India’s pre-Britain past, he maintains that ‘at the same time, I should not be overlooked that India, if left to herself, might have found in the course of time a shorter and surely less tortuous road towards a better and richer society’ (Larrain, J, 1989:86) This study can be highlighted as a powerful insight of the classical dependency theories which has directed researchers to examine the process by which foreign domination had shaped the development of Third World countries.  (So, A, Y. 1990:129)Overall, the work of Paul Baran can be considered a very important landmark in the refurbishing of the theory of imperialism after the Second World War. He introduced such crucial changes to it that it is possible to argue that his contribution is the hinge which joins or articulate the theory of imperialism with, and marks the beginning of dependency theory. (Larrain, J, 1989:115) Andre Gunder Frank Andre Gunder Frank was one of the key figures under the Dependency Theory as well as the first to write in English.In his most influential writings ‘The Development of Underdevelopment (1969)’ Frank drew inspiration from Paul Baran, focusing upon the dependent character of peripheral Latin American economies, and was able to conceptualise Baran’s notions in terms of a capitalist world system of metropolitan and satellite areas. Metropolitans are countries that are considered as the colonizers or developed countries and the satellites on the other hand are the colonies and considered underdeveloped countries.Satellites supply cheap primary commodities to the rich countries that then use the raw materials to produce specialized good, and then send them back to the satellites for profit. Frank argues that this metropolished-satellite relationship is only in existence to serve the â€Å"interests of the metropoles which take advantage of this global, national, and local structure to promote their own development and the enrichment of their ruling classes† (Moses, D, 2012.)He argues that the reason why LDCs are getting poorer is because the exploitation it experiences from the DCs such as extracting raw materials from the LDCs while the DCs manufacture, deliver and sell the final product to LDCs with a price hitting the ceiling. In his famous writing entitled as Dependency theory claims that the r elation of imperialism and domination trapped poor nations at the bottom of the global economy.  (Larrain, J, 1989:115)Frank purposed four hypotheses, one being â€Å"the satellites experience their greatest economic development and especially their most classically capitalist industrial development if and when their ties to their metropolis are weakest† (So, A, Y. 1990:98) Therefore, his solution to the problem was that Third world countries â€Å"de-link† themselves from the world market, allowing them the opportunity to develop instead of distributing their own resources to the metropoles.However, as stated previous, due to military force or economic sanctions this may not be possible. By escalating Baran’s views and adapting them to the analysis of the Latin American situation, Frank’s idea that capitalism expanded from Europe and managed to incorporate the whole world in a single international system, quickly became well known all over the academic world and gave intellectual currency to dependency theory.Critique of classical dependency studies and modification by new dependency theorist The dependency perspective seems to have been particularly popular during the 1960s, but based on the classical dependency theories outlined above, it has since lost some of its attraction and has been the subject of a great deal of criticism since the 1970s. Firstly, it can be claimed that dependency theory itself was betrayed by the very formulation of its name. Many critics argue that it is not a theory, but can more accurately be conceived of as an approach to the study of underdevelopment.In fact, new dependency theorists such as Cardoso objected to the term ‘theory' to describe it. He believed it is an overarching framework within which one might formulate specific hypotheses/theories, a ‘methodology for the analysis of concrete situations of dependency. ‘ It did not predict determinate, discrete outcomes. Rather, it sought to provide a new perspective from which to examine the problematique of economic backwardness. (Cardoso, F, H. 1977:15) For many social scientists the methodological faults of the approach were too obvious to ignore.As stated earlier, the dependency theory arose as a critique of the modernisation theory. However, the modernisation school fought back, characterising the dependency perspective as a propaganda fragment of Marxist revolutionary ideology. Instead of providing a scientific analysis of what has actually happened in third world countries, the concept of dependency has become an all-purpose explanation for everything that is wrong with third world countries (So, A, Y. 1990:131) Another methodological criticism was that classical theorist Baran and Frank committed a major error of treating all peripheral areas as if they were the same.Fernando, H, Cardoso is usually singled out as the key figure of the new dependency studies. Unlike the general analysis of the classica l dependency school, Cardosos methodology is â€Å"historical-structural†. (So, A, Y. 1990:135) Therefore, he paid more attention to historically specific situations of dependency than classical theorist Baran and Frank. In this work, Cardoso pointed out that the shift from the Brazilian populist regime to military regime was represented as the pursuing of a new model of â€Å"associated-dependent development† in Brazil.He added that there were many new activities, which has been done by military regime in Brazil. Goertzel (1999) suggests that Cardoso’s success: ‘†¦ has come not because he has had a better theory but because he has always kept one question at the center of his thinking: What will happen if society selects one course of action over another? To answer this question, he has focused on the sociology of the historical conjuncture rather than on general theory†¦ ’ (Goertzel, T.  1999:182)However, Cardoso work too received much criticism for his esoteric style of writing. One scholar, assessing Cardoso and Faletto's Dependency and Development, decries the authors' â€Å"ornately Hegelian style† which is held to be partly responsible for the â€Å"confusing and even contradictory† message of dependency theory (Staniland, M. 1985:134). However, Cardoso himself admitted that â€Å"if there have been so many distortions in the consumption [of dependency theory], it is because the original production was not clear regarding several points† (Cardoso, F, H.1977, 17).Dependency theorist overemphasised the factor of external conditions, and neglected the role of internal dynamics such as class conflicts and the state. Petra’s (1982) indicated that â€Å"to conceptualise the issues of the Third World in terms of dependency is to lose sight of the most decisive processes class formation and social relations which beget change and the particular configurations of social forces which emerg e on a world scale†. (Petras, J.  1982:148)New dependency theorist Cardoso overcame this weakness by focusing on the internal structures of dependency. According to Alvin Y. So â€Å"Cardoso is more interested in analysing the socio-political aspect of dependency, especially class struggles, group conflict, and political movements† (So, A, Y. 1990:136) Classical dependency theorists have become subject to criticised on policy implication. The dependency perspective emphasizes the harmful effects of colonialism and international division of labor.But in fact, the success of countries such as India, south Korea and Taiwan have proven this idea wrong, especially Baran’s study on colonialism who once believed India moved backwards, from a relatively advanced industrial nation to a backward agricultural nation with the belief that it would never escape the British rule and develop again. Dependency may not lead to underdevelopment and as such periphery countries mov e from â€Å"underdevelopment† to becoming serious economic heavyweights it can be used to argue against the theory.Unlike classical dependency theorist (e. g.  Landberg) who portray the miracle of East Asian development as â€Å"manufacturing imperialism† New dependency theorist Thomas B Gold (1986) uses the concept of â€Å"dynamic dependency† in his study of Taiwan’s development. Taiwan’s starting point of development was in most ways very similar of that of Latin American countries. Like other colonial governments, the Japanese implanted a structure of dependent capitalism in Taiwan and skewed the economy to the production of two primary good (rice and sugar). Gold believed that Taiwan was undeniably restructured by Japan, it was not underdeveloped.Soon after World War 2 Taiwan broke free from the Japanese colonial rule and have attained rapid economic development. (So, A, Y. 1990:158) Therefore this rejects classical dependent theoristâ€⠄¢s assumption that this is impossible for a country to develop if it has experienced colonialism. Furthermore, determinism also burdens dependency with what Stephan Haggard has called the ‘structuralist paradox'. â€Å"The model was outlined to help identify the international constraints associated with certain development paths in order to overcome them.†However, dependency does not allow for the possibility that particular state strategies may act to reduce those international constraints. (Haggard, S. 1990: 21) In response to this new dependency theorist such as Cardoso view dependency as an open-ended process. Unlike classical predictions of unidirectional trend of underdevelopment in Third World countries He argues â€Å"that there can be development and dependency and that there exist more dynamic forms of dependence than those characterising enclave or quasi-colonial situations† (So, A, Y.  1990:137)Even though the new dependency perspective has modifie d some of the classical dependency perspective, they still share the same concept such as focus research is Third world countries, national level of analysis, and center – periphery dependency. According to Larrain â€Å"Dependency analyses share similar interests in studying the situation of peripheral capitalist countries from the point of view of the conditioning effects which external forces and structures produce on the internal structures of these countries† (Larrain, J. 1989; 112) ConclusionIn conclusion this essay has demonstrated an overall understanding of dependency theory, by originating back into the 1940s where it all began, following up to its relevance in today world. As well as the strengths of the theory, the essay has discussed the ways in which dependency has been subjected to a barrage of criticism on theoretical, empirical, methodological, and stylistic grounds. Furthermore it has researched and demonstrated how new dependency theorists have modif ied classical dependency studies in order to overcome their weaknesses.Overall I feel that Cardoso’s analysis in more sophisticated than the classical dependency studies. His work has added the lack of explanation in the classical work; it has improved on many of its criticisms and emphasizes broader explanation on what happen in the third world. I also believe that Cardoso’s research, along with Gold’s study of Taiwan’s, has shaped the direction of empirical studies in the dependency school and started a whole new investigation on dependent development in the third world.

Tuesday, July 30, 2019

The International Strategy of TESCO PLC

Abstract This study explores the different theories of international entry strategies and then analyses the international strategy of Tesco Plc. Firms can enter the international markets through different strategies, including licensing technology abroad, direct investment acquisition, exporting, strategic alliance in foreign market and establishing joint ventures. The findings of this study indicate that Tesco Plc uses international joint ventures, acquisitions and Greenfield investments to enter into foreign markets. However, Greenfield investments have led to failures and as such it is recommendable that the company explores international joint ventures and acquisitions as part of its future entry strategies. Introduction International strategy is very important for all business organisations operating in the international market. This is because the strategy plays an important role in determining the opportunities present in the international market and how to exploit them (Hensmans et al., 2013). Tesco Plc. is one such company with significant development in the international market. The supermarket chain has managed to expand its operations across Europe, Asia and North America with huge success. This international expansion has affected all the facets of the company like business structure, financial status, corporate culture and organisational structure (Ryans, 2013). This study looks at different international strategies, why they are important to Tesco Plc, related theories and their applications. International Strategies The current business environment is very competitive and as such companies need to venture into the international markets in order to generate more profits (Hitt et al 2008). However, choosing the right international strategy is never easy; whether it is licensing technology abroad, direct investment acquisition, exporting, strategic alliance in foreign market, or establishing joint ventures. This study will focus on a few of these strategies that are of importance to Tesco Plc. These strategies are joint ventures, foreign acquisitions, and Greenfield investments. All these strategies have their own benefits and risks arising from the products or services being offered and the cultural, economic and political environment of the target market (Sternquist & Witter 2011). However the choice of the choice of international strategy is highly dependent on organisational resources, commitment and the extent of risk that it is willing to incur. Joint ventures involve cooperation among different companies. The partners often come together to consign risks, allocate resources and delegate responsibilities (Krafft & Mantrala 2010). These ventures are often disbanded once the project is completed. Joint ventures can enable an organisation to market its products or establish its manufacturing plants in a foreign country with the assistance of the local foreign partners. These local partners equip the foreign organisations with the relevant knowledge on government regulations, workings, local markets and the available channels of distribution. Joint ventures are ideal for Tesco Plc. as it will help it in understanding the foreign markets and mitigate risks (McLoughlin & Aaker 2010). In foreign acquisitions a foreign organisation acquires an interest in a local firm through foreign direct investment (Hensmans et al 2013). In most cases foreign acquisitions occur only in proven markets after years of exporting or success experienced through existent joint ventures. Once an organisation has obtained controlling interests, it attains full authority over policies regarding aspects like quality control, finance, production, marketing strategies and expansion programs. Foreign acquisitions are ideal for Tesco Plc. as it will help it acquire other companies that are already performing well in foreign markets. The last strategy is Greenfield investment which is a type of foreign investment that entails investing in foreign markets by starting new subsidiaries and then fully owning them. This is a strategy that is suitable for Tesco Plc. because it allows it to venture into new unexploited markets and exploit the opportunities present. Theories of International Strategies There are different theories that explain the reasons why an organisation opts to pursue a specific international strategy in a specific target market. This is the reason why organisations pursue different foreign markets using different strategies depending on their unique characteristics (Hitt et al 2008). These theories are monopolistic advantages, transaction cost, internalisation, strategic behaviour, internationalisation, bargaining and eclectic theories. These theoretical perspectives at times hold divergent perceptions on the relative importance of the different factors that influence choice of entry into foreign markets. The monopolistic advantage theory was proposed by Hymer and represented a major shift from the previous theories of capital investments and international trade (Sternquist & Witter 2011). The previous theories like that of Heckscher and Ohlin had restrictive assumptions on the immobility of the factors of production. Hymer argued that organisations could use their firm-specific advantages or monopolistic advantages that other organisations do not have to expand into foreign markets. These advantages are things like superior technology, economies of scale, superior knowledge in finance, marketing or management (McLoughlin & Aaker 2010). Therefore foreign direct investment was made possible by product and market imperfections. These market imperfections are structural and are as a result of control ownership advantages like proprietary technology, economies of scale, special access to inputs, product differentiation and gathered managerial expertise. According to this theory, the dir ect investor is often a monopolist or an oligopilist in product markets. Therefore these organisations pursue market power and monopolistic advantages in the foreign markets leading to the increased growth of international trade. Internationalisation theory builds on the monopolistic advantage theory and it holds that firms often expand into foreign markets whenever there are market imperfections and they can gain advantage by internalising markets across countries (Seth & Randall 2011). This results to the growth of the firms as they increase their operations across the borders to take advantage of the existent opportunities. As the organisations increase their efficiency through internalisation of transactions, the vertical integration of operations across the world lead to efficiencies and economies that include long term contracts, opportunity to exploit tax differentials and better quality control. The theory perceives the internalisation process and entry strategies as being products of series of incremental decisions that result in increases involvement in international operations (Alexander & Doherty 2009). Therefore firms move from exporting to foreign production as they continually gain internatio nal experience. This experience enables the firms to build their knowledge and developing deeper understanding of the foreign markets. The transaction cost theory holds that firms try to minimise the costs associated with exchanging resources with the environment and the bureaucratic costs of exchanges within the firm (Krafft & Mantrala 2010). Therefore they weigh the costs of exchanging resources with the environment against the bureaucratic ones that arise from performing the same operations within the firm. It perceives institutions and markets as possible forms of organising and coordinating economic transactions. Firms grow whenever the external costs exceed the internal bureaucratic costs because they are able to operate more cheaply compared to performing the same operations in the market (Seth & Randall 2011). However, the firms should be downsized whenever the bureaucratic costs exceed the external transaction costs. Therefore the firms will keep expanding for as long as they can perform their operations cheaply within the companies compared outsourcing them to external market providers. The bargaining theory was advocated by Fagre and other scholars and holds that the choice of entry is a function of the bargaining processes between the firm and the host countries (Ryans 2013). The interaction between the host country and the firms is often characterised by power struggles. Although the host country can exercise its bargaining power through controlling market access, the bargaining power of the firms lie in the ownership advantages that they have (Hensmans et al 2013). Therefore the relative power determines the entry strategy of a firm into a foreign market. The last theory is the strategic behaviour theory and it is based on the premise that firms derive comparative advantage from the resources that contribute towards giving them the advantage over the others (Thain & Bradley 2012). This is particularly true when some resources are worth more to an organisation owing to the special linkages between the firm and such resources. When the firms have such resources, t hey are more likely to opt for high control strategies for instance wholly owned subsidiaries. This decision is mostly made with the assumption that such linkages will be influential in enhancing the relative position of the firm in the new foreign market. In addition to the highlighted theories, the integrative theoretical perspective on foreign market entry holds that the firm’s decision to enter into a foreign market and its choice of entry are functions of multiple factors that arise from location and ownership-specific advantages (Alexander & Doherty 2009). Although these theories differ in many important aspects they allow for broad generalisations on the factors that influence an organisation to enter into a foreign market and the entry strategy. The next section analyses the international strategy of Tesco Plc based on the integrative framework. Tesco Plc International Strategy The company enters foreign markets mainly through joint ventures with local firms, acquisitions and Greenfield investments (Mosley & Barrow 2013). The company aims at being the market leader in the foreign country it enters within a period of five years. It has registered huge successes in Asia and most of the European markets. However, the situation in America has been different because the company has struggled to gain market control (Harrison 2013). The success of Tesco Plc in the international market has been aided by its sensitivity to the local culture of the host countries and the market environment. This has mainly been done through partnerships, mergers and acquisitions which have made it easier for the company to offer the local markets with what they want by serving their unique needs. This has been particularly helpful in high context cultures like in the Asian market. The global expansion and diversification of Tesco Plc are based on the long-term desire for the company to develop sustainable growth and development. Morschett (2011) claims that one of the main reasons why the company decided to pursue the international market was that the local UK market had reached saturation and maturity making it very difficult to grow without exploiting overseas opportunities. This was therefore the only viable solution for the company if it was to remain relevant for the economy in the long run. The main factors influencing the choice of entry for Tesco Plc are the different threats that it may encounter in the international markets. Some of the common threats are industrial structures and cultural factors. Nonetheless, the primary influencers of the choice of entry for the company are based on cultural factors (Harrison 2013). Tesco Plc has consistently preferred to use international joint ventures as an entry strategy in the Asian market. This is partly because these countries have high context cultures that require organisations to build interpersonal relationships (Alexander & Doherty 2009). In these cultures, relationship networks among business associates, colleagues and even clients tend to be close and personal. As a consequence, it is important for firms to build trust and relationships during business interactions. The importance of these relationships arises from the fact that they have high uncertainty avoidance levels; therefore relationships and trust reduce the level of uncertainties, risks and ambiguities (McLoughlin & Aaker 2010). For instance in South Korea, the international joint venture with Samsung helped the company establish contacts with the local suppliers and manufacturers. This was very important in penetrating the market in South Korea because the customers there often shop freq uently as they prefer fresh and quality products like vegetables and meat which is different from the customers in the UK who like piling stock. Based on the internalisation theory, Tesco Plc gained advantage by internalising the market in South Korea. This was done through building local networks to ensure that the company sales remain as high as possible. Therefore it employed all the employees of Samsung to ensure that the normal operations were not interfered with. The local managers were also given the authority to make decisions on behalf of the company because of their experience with the local market. Additionally, this was part of the company’s plan to deal with the challenges associated with the competitive environment by positioning itself using localisation and decentralisation while the other players in the industry pursue globalisation strategies (Hitt et al 2008). According to the bargaining theory, localisation and decentralisation gives the company a local im age thus making it highly responsive to the tastes and lifestyles of the local consumers. This gave Tesco Plc a competitive advantage in the South Korean market compared to the other foreign firms like Wal-Mart and Carrefour. The entry strategies of Tesco Plc have also been shaped by cultural factors like psychic distance. Psychic distance refers to the extent to which a firm is uncertain on the nature of the foreign market (Thain & Bradley 2012). Acquisitions and international joint ventures with the local businesses in the high context cultures are important in reducing risks, adaptation costs, psychic distance and cultural barriers. The acquisition of the local distribution channels gave the company a huge advantage over the other multinationals like Wal-Mart which were struggling because the Korean market is characterised by a strong nationalist outlook. The company pursued the same strategies in Thailand and China and this enabled it to penetrate the market with ease compared to other multinational companies. Therefore international joint ventures and acquisitions enabled Tesco Plc. to succeed in markets where Carrefour and Wal-Mart had failed eventually being forced to exit the market in 2006 (Mosle y & Barrow, 2013). In Thailand for instance, after the acquisition of Lotus, Tesco Plc has managed to grow and is currently the market leader as it has pumped huge investments into organic management. The company also diversified its operations in Thailand to include smaller express stores so as to reach more customers. Tesco Plc has made huge successes whenever it chose to enter foreign markets through strategic alliances and acquisitions; however Greenfield entries have proved to be costly and inappropriate. Although Greenfield entries provide the company with full control and ownership over its operations, it has proved to be unsuitable because of the dismal results. Despite the extensive research that the company made prior to joining the US market, its failure there demonstrates that the research was either flawed or inadequate (Krafft & Mantrala 2010). Additionally, its operations in the US were an attempt to duplicate its operations in the UK because it tried to standardise instead of localising them. Part of the problem with the market research was that it only concentrated on the buying behaviour of the Americans and ignored other important variables like shopping experience, value, aesthetics, store atmosphere and quality. This was a great mistake because corrective investments should have been made in response to these marketing aspects (Morschett 2011). For instance the Tescosells pre-packaged fruits was a big mistake because Americans prefer selecting their own fresh fruits. Tesco failed to appreciate the US customer base because it underestimated it. This is the reason why the company handled its operations in the US as an extension of the UK market. The company was attracted to the US market by the booming economy and the ever rising property value (Ryans 2013). These are the factors that prompted it to go for Greenfield investments in US. This was a viable option; however the company failed to account for the deeper financial dynamics that could have saved it from the 2009 financial crisis. In addition to this, the choice of Tesco Plc to enter the US market through Greenfield investments was partly influenced by managerial short termism and egoism. As a consequence, several mistakes can be pointed out from its entry and post entry strategies. The first mistake that the company made at the point of entry is that it increased its exit barriers by aggressively increasing more stores despite the fact that it was making huge losses. Secondly, the company may have been driven by managerial subjective interest for power emanating from the previous international successes. This led to overconfidence therefore blurring the vision of the managers to see that they were driving the company in the wrong direction (Morschett 2011). However, the biggest mistakes that Tesco Plc made was that it failed to plan and strategize for post entry and this led to flaws in its quest to compete in the home market of the world’s largest retailer. As a result the company made huge loses in the US and was eventually forced to exit without ever recording any profits. In Taiwan, the situation was the same as that of the US; Tesco entered the market in 2000 without partnering with the local companies. The company was able to establish six hypermar kets through organic growth. However, just like in the US the Taiwanese retail market was hugely dominated by Carrefour which had the advantage of having all the strategic positions. Just like in the US, the company was unable to attain the market scale necessary for building central distribution centres. Therefore in 2005, it was forced to exit the market through a divestment deal with Carrefour. Recommendations Based on the findings of this study, the following recommendations can be made for Tesco Plc for it to succeed in its quest to establish its presence in other international markets. First off, the company should abandon Greenfield investment strategies because they have proved to be very costly in the past. The company struggled in the US and Taiwan and was eventually forced to exit because lack of local partners made it very difficult for it to succeed in markets that are dominated by the two retail giants. The company should have strategies that fit into the culture of the target market like it did in South Korea. The retail industry is very sensitive because it represents the daily necessities of the consumers and as such must be responsive to their cultural habits. For a multinational company to succeed in a foreign market it must have strategies that are responsive to the needs and culture of the local people. Therefore Tesco Plc. should continue incorporating localisation strat egies and respond to the culture of the local markets. It should be more innovative and proactive in its marketing strategies in the international markets. For instance the company should enhance its market intelligence and customer database in order to be able to customise service delivery to the customers. References Alexander, N., & Doherty, A. M. (2009). International retailing. Oxford: Oxford University Press. Cunningham, J., & Harney, B. (2012). Strategy & strategists. Oxford: Oxford University Press. Harrison, A. L. (2013). Business environment in a global context. Oxford: Oxford university press. Hensmans, M., Johnson, G., & Yip, G. S. (2013). Strategic transformation: Changing while winning. Houndmills, Basingstoke, Hampshire: Palgrave Macmillan. Hitt, M. A., Ireland, R. D., & Hoskisson, R. E. (2008). Strategic management: Competitiveness and globalization. Mason, Ohio: South-Western. Krafft, M., & Mantrala, M. K. (2010). Retailing in the 21st century: Current and future trends. Heidelberg: Springer. McLoughlin, D., & Aaker, D. A. (2010). Strategic market management: Global perspectives. Hoboken, N.J: Wiley. Morschett, D. (2011). European retail research: Volume 25, Issue I. Wiesbaden: Gabler Verlag. Mosley, R., & Barrow, S. (2013). The employer brand: Bringing the best of brand management to people at work. Hoboken, N.J: Wiley. Ryans, A. (2013). Beating low cost competition: How premium brands can respond to cut-price rivals. Hoboken, N.J: Wiley. Seth, A., & Randall, G. (2011). The grocers: The rise and rise of the supermarket chains. London: Kogan Page. Sternquist, B., & Witter, G. (2011). Retail strategic international expansion (SIRE?) theory and cases. Haslett, MI: BSC Publisher. Thain, G., & Bradley, J. (2012). Store wars: The worldwide battle for mindspace and shelfspace, online and in-store. Chichester, West Sussex: John Wiley & Sons.

Monday, July 29, 2019

Constitutional Considerations Research Paper Example | Topics and Well Written Essays - 250 words

Constitutional Considerations - Research Paper Example It is hard to prosecute someone for crimes committed in another jurisdiction (but it is possible). Generally speaking, the worse the crime the higher the level of jurisdiction. For example, most terrorism charges are of a federal nature and will be tried in federal court because they are matters of national security. |The government has decided that one type of crime is more severe than another and that it affects the national interest. Additionally if a crime involves several states—for example, if you rob banks in Vermont, New Hampshire, and Rhode Island, federal prosecutors will likely take over. Additionally, if a crime involves moving money in and out of the country, federal prosecutors will likely take over. Or if a crime such as corruption is occurring at the State Capitol, the FBI will be called in. Generally, there are a number of federal organizations such as the FBI, ATF, and DEA who have federal jurisdiction over certain serious types of crimes. These people will d o their investigations and turn over their evidence to federal prosecutors who will then make their case to a federal judge. All of these people will have been appointed by the federal government. Jurisdiction is the place of the

Sunday, July 28, 2019

Safeguarding Vulnerable Adults brochure Essay Example | Topics and Well Written Essays - 2500 words

Safeguarding Vulnerable Adults brochure - Essay Example It is the sole responsibility of the gov- ernment through the docket of health to protect vulnerable adults by enacting laws and policies in favour of the physi- cal, financial, and emotional well-being and security. adult. The need to control environmental health hazards is addressed here. This will help prevent vulnerable clients from living in conditions of extreme sordid dirtiness and lack of hygiene. The fact that most physical and mental help them, while they are physically and mentally advan- taged to decide on whom to handle their welfare on their behalf should they become vulnerable. Family members also protect the individual from molestation and domestic assault. respond appropriately to incidences of abuse reported to them in a manner that will facilitate acquisition of relevant information. A nurse or doctor must listen carefully and actively to what the client is reporting and record vital information. sive report (Myall et al. 2009). The client must be reassured that he or she has done the right thing to report any form of abuse and that inform them the next course of action as well as people who are

Saturday, July 27, 2019

Marketing Strategy Essay Example | Topics and Well Written Essays - 1000 words - 3

Marketing Strategy - Essay Example The customer has become very choosy and thus he relies more on the communication messages that are put up on the web and other media forms, rather than relying on the TV and newspaper advertising which are some aspects that are a thing of the past (Palser 2007). The customer becomes active nowadays when he realizes that the Internet is a potent force and anything that is put up on it will surely make a huge difference within his life. Also there have other forms of advertising which have literally changed the face of the conventional ways of reaching to the intended target audience. These include the transit advertising forms, the street and pole signs, the road branding techniques, the balloon advertising and so on and so forth (Ha 2003). What all these advertising methods have brought forward is the fact that the customer has become very educated and that he does not need to have a TV or a newspaper to access details about the brand or service which is being highlighted, from the domains of the client in essence. The customer now knows that if he has missed TV and newspaper advertising, he can most definitely go on the web and easily access the same. He can go outdoors and see the street signs and hoardings and thus be in line with whatever is being offered to him all this while. The death of TV and newspaper advertising has happened over a period of time, and not in an overnight fashion (Stoff 2008). This has meant that the TV and newspaper owners had started to understand that their respective mediums have lost the battle as compared to the newer media outlets and methodologies which were making serious mark on the consumers’ minds. What is even more interesting is the fact that the consumers have now realized that the power of the contemporary forms of advertising within their lives has become very significant and that they would rely on

Chinese politics and government Essay Example | Topics and Well Written Essays - 1500 words

Chinese politics and government - Essay Example Key characteristics of the Leninist-Marxist Influence on the Chinese government include: 1. Inevitable goals and Philosophical absolutism. The Chinese communist regime claims to possess universal and absolute truth (Guo 110). Marx’s dialectic and historical materialism are the main source of the communist party’s declaration of inevitable goals and universal truths. 2. The communist party’s Leninist party-state official, paramount and exclusive ideology that serves to justify the CPC’s political actions and goals. (Guo 91-108) Confucianism The main philosophical base that shapes the traditional Chinese political history and culture is Confucianism. It is a philosophy that can arguably be described as being hostile to individualism and any autonomy on the part of the individual; instead it encourages the individual to make self sacrifices on behalf of the state. This is considered to be the highest ideal of citizenship (Guo 47-56). Confucianism started domi nating Chinese thought shortly after 200 BCE and it was generally the main Chinese orthodox ideology for a period of over 2000 years before 1911. Despite the changes to the social and political structure imposed by the communist government, many Confucian ideas still remain and play a prime role in influencing Modern China’s main political culture (Guo 47-56). Influence of Russian Communism The inspiration for the formation of the Chinese Communist Party (CPP) came from the Russian Revolt. The party was formed by Li Dazhao and Chen Duxiu in June 1921. Mao Zedong quickly became the most important member of the newly formed CPP and he adapted ideas that Lenin had used to achieve a successful revolution in Russian in the year 1917 (Guo 59-62). The May 4th Movement Due to the influence of the Chinese October Revolution, the May 4th Movement quickly came. The movement sprang up on May 4th 1919 and was in protest of the government’s perceived feeble reaction to the Treaty of Versailles; this is especially in the light of the Shandong problem. The movement had anti-feudal and anti-imperialist principles and set the stage for the continuous funding of the Communist Party of China. This is as a result of Marxism-Leninism ideologies linking themselves with the ongoing revolutionary practices of the people of China. Effect of Foreign Invasion and Historical Trauma The Communist Chinese government adopted the principle of â€Å"taking what is best† from the outside world during the 19th and 20th centuries. This was done in an effort to import only the positive things from the Western world while keeping out of China all the influences that they perceived as having a humiliating or weakening effect on China. This was especially manifested between 1946 and the late 1970s when mainland China was nearly closed to much of the outside world. The negative feelings that China derived from its foreign contact are still evident and linger under the surface in m odern day China. Similarities and Differences in Organization, Ideology and Power in Contemporary and Traditional China. Throughout the history of China, there has been a continuous emphasis centered on the maintaining and creation of order via the establishment of a benevolent authority that is usually perceived as playing what is considered to be a central role in

Friday, July 26, 2019

My personal Activities Statement Example | Topics and Well Written Essays - 500 words

My Activities - Personal Statement Example In this case, I involved myself in cleaning the community waste since this is the recommended way of presenting environmental problems in the media. I also involved myself in conservation of the environment since it is my major area of interest. When a chance is available, I enjoy working in the field. Also, in the same 2007, I joined in the composition contest at the International Alkema Contest (IACC). I succeeded in the first IACC edition. The composers irrespective of the age could subscribe to the contest. The composition contest contained all styles of preferable classical music with popular music like rock, folk, pop, and jazz. I received the guitar and the piano award after being the best pianist. In 2008, I was among the competitors in the National Mathematics competition. I managed to enter the semi-finals that were much tougher that I could expect. The competition consisted of 20 multiple choices with a two division grading criteria. I managed to win the competition and awarded $1000. In 2009, I engaged in robot composition. As a group of five students, we designed a team brand robot which was programmed to perform instructed tasks. We gained popularity from the competition since it was successful. The robot could do minor mathematical calculations within a restricted time limit. In 2010, I saw old men struggling at homes due to their poor health. I took the priority to join in community volunteer activities in order to nurse the old men at home. Most of the men were unresponsive, depressed, and mentally disturbed due to health and family issues. As a group of volunteers, we were able to nurse them through special guidance. In early 2011, I gave not only a motivational talk, but also an educational guidance basing on career choices among the high school students. I was able to visit Thomas Jefferson High School for science and Technology and Oxford Academy in US for the talk and guidance. In 2012, I joined the

Thursday, July 25, 2019

CI Essay Example | Topics and Well Written Essays - 3750 words

CI - Essay Example Another impact of this study of effects of merger events is the impact it has on the competitiveness of the post merger firm in terms of profitability and efficiency. The competitiveness is a critical aspect to be considered by investors and managers before deciding on whether a merger is an appropriate financial decision to make. The way stock markets react to events around a merger and specifically the announcement of a merger can be used to reasonably predict the future financial and operational performance of firm in a financial market so long as it is efficient. This research looked at the stock performance of some of the listed stocks before a merger announcement and after the announcement. The daily stock prices were noted and analyzed statistically to highlight the changes in return and correlated with the stated event and other similar competing firms’ stock prices. It was generally noted that the announcement of a merger generally resulted in certain changes in the p rices of stock. Review of literature points out that there is a negative correlation between the stock returns and hence the value of the firm after an announcement of a merger. This could be explained using hypothesis put forward by behavioral finance scholars. This particular empirical study further reinforces the studies in which the post merger firm values as indicated by the stock prices using the cumulative average abnormal returns CAARs reduce with the announcement of a merger, just a few days of the announcement and well after the announcement has reached the public. Introduction Economists and financial analysts are sometimes faced with the challenge of figuring out the magnitude of the effect an economic event has on the underlying value of firms. This implies that they have to measure the impact based on a particular cause or event. To achieve this the event study methods have developed that assist in the construction of effective models that easily predict the value of a firm based on an event. This is basically an event study that employs residual analysis to evaluate and analyze how a market behaves to an announcement of a merger. A company merger would mean that a company would inherently have more capital size, increased in operations and more diversification. This however does not always result in improved profitability as it could be hindered by excessive costs of acquisition and regulation obstacles. In previous studies it has been noted that an event such as the announcement of a merger had a positive market reaction. This can be investigated using abnormal stock returns noted during such events. As earlier stated the announcement of a merger and or acquisition shall be regarded as the event for the purposes of this study. This research paper has the following objectives: (a) to investigate whether news or any other publicly available information can influence the price patterns of the acquirer and (b) to examine the impact a merger announc ement has on the stock prices of the acquired. The research shall be carried out by comparing the stock prices and daily returns before the merger announcement and immediately after the merger announcement using the daily closing stock prices. This particular paper is organized into four sections. The first section shall review the literature on previous research on event studies related to mergers

Wednesday, July 24, 2019

Eulogy for Willy Loman Essay Example | Topics and Well Written Essays - 500 words

Eulogy for Willy Loman - Essay Example We got married and I became his legal, and beloved wife all his life. We had two children who happened to be both boys. Our sons are named Happy Loman and Biff Loman. Happy is a businessperson and Biff Loman who is a good athlete and is the late Willy’s eldest son. The deceased was a brother to the late Ben. My brother in law Ben was an elder brother and a mentor to my husband. The late Willy was an industrious man who worked under Howard Hagner as a salesperson for a period of 34 years. He worked through the vicissitudes of his employment with meager wages, and tirelessly tried to ensure that we educated our two sons and offered necessary guidance when it came to our sons’ future success and prosperity. When he met his death, he was always on board since his job involved a lot of travelling to different cities. He was mobile, traversing the country also lived in Boston where we had another house. In spite of being regarded a non realist, I knew my husband liked people and was liked back by our neighbors among them Charlie and will be remembered for he was fond of playing cards. He maintained good relations with his employer and enjoyed in the greatest bit his work. Willy was a loving husband and greatly loved by his wife Linda. He was a father with resolute and strong stand on matters that pertain to our sons irrespective of being viewed not to be in touch with realism. Before he met his death, my husband was involved in a series of unexplained accidents unt il the recent one that ultimately killed him. He always survived these accidents. However, before the final accident, he uttered decisive words just before he left the house. He was upset and mentioned to me something related to his funeral attendance and how it will have a multitude. These words he told me, are those that today make his death presumed a suicide. Nevertheless, my husband died on road carnage just like he previously did but the latter was severe and

Tuesday, July 23, 2019

Critical analysis of market access with regard to the ECJ rules on Outline

Critical analysis of market access with regard to the ECJ rules on free movement of goods - Outline Example To be noted in this regard, ECJ has imposed a few laws regarding the free movements of goods and market integration within EU member states. ECJ has also imposed several laws that has emphasised environmental protection as well as social policies ensuring transparency and equality to a considerable extent2. Based on this understanding, the study intends to examine the pros and cons associated with the free movement of goods allowed by ECJ, to obtain a critical purview of the market access enjoyed by participant countries. An elaborated rational will be delivered regarding the method to be used when considering the stated aim for this study. To be noted in this regard, as the study will follow a qualitative approach, it is important to determine the variables to be considered when performing the intended thematic analysis of the gather information. With this emphasis, the chapter will hence discuss about the assumptions taken to interpret how market access to EU, for the member states as well as for the foreign nationals, are getting influenced by the prevailing free trade regime as per the ECJ. This chapter will elaborate on the importance of ECJ over internal market integration. This particular chapter will therefore contain a critical review of the viewpoints presented by researchers that will help to provide a detailed overview regarding the ECJ’s contribution towards the market integration. A methodological brief of the study will also be delivered in this section wherein the rationalisation will be provided concerning the selection of the literature. To be stated precisely, literature published within the span of past 10 years will be considered for the study, although this bar of the mentioned period will be ignored when referring to cases. That is, cases must be relevant to free trade of goods in EU and be registered under ECJ to be

Monday, July 22, 2019

Teachers Day Essay Example for Free

Teachers Day Essay Ratna: A timeless Indian edict goes â€Å"Mata Pita Guru Deva† which translated stands for â€Å"Mother Father Teacher God† – a sacred list of the most revered relationships in a strict order. The meaning of this adage is the greatest truth, and is the order in which one should offer reverence. The phrase is a basic tenet in existence from the time of the Vedas and beyond. Snehal: First comes the mother (Mata) who gives birth to the child, thereby bringing us as a child into this world. Next comes the father (Pita), because it is the mother who knows the truth about the father and she points us to the father. The mother and father then take us to the teacher (Guru), and it is the guru, through his or her teachings, points us to God (Devam). Here God represents the consciousness or self-awareness or our real self. A Teacher thus stands at a higher pedestal than the almighty omnipresent, omnipotent, omniscient and omnifarious. Ratna: Most of our earliest memories of school days will definitely feature an ever-smiling, ever-helpful teacher who assumed the role of a parent at school. While in many relations, we tend to pay back, with gratitude, the service or help rendered to us, a Teacher-Student relationship mostly ends up as a one-way lane where the teacher is always the giver and seldom the receiver. Snehal: So, here we r today to celebrate the magic, the â€Å"teacher† by expressing r deepest sense of gratitude and respect In our little way to wish to thank u all and salute ur immeasurable efforts and hard work†¦ I, Snehal and my friend Ratna, on the behalf of r entire class and r seniors welcome u all here†¦ Ur presence and valueable time really means a lot to us†¦ Welcome and hope u have a memorable Teachers Day†¦ 1) Ratna: (Ankit and Shankaran) In the words of William Butler Yeats, Education is not the filling of a pail but the lighting of a fire. Without any further delay, taking blessings from the almighty and r teachers here, I will like to welcome Shankaran and Ankit to begin with the program and fill d air with music and melodies†¦ 2) Snehal (Vikram speech) Thank u Ankit and Shankaran for a great start†¦ Before we move any further, I would like to invite the President of the Management Association and r dear senior- Vikram Sir to come up and lead the way forward by saying a few words†¦ 3) Ratna (Ppt) Nikos Kazantzakis has rightly said- â€Å"Ideal teachers are those who use themselves as bridges over which they invite their students to cross, then having facilitated their crossing, joyfully collapse, encouraging them to create bridges of their own†. N its owing to those great teachers u n I stand here today†¦ Here we present a small presentation as a token of r appreciation towards u all teachers†¦ 4) Ratna (Harshit) Someone once said, â€Å"Most of us end up with no more than five or six people who remember us. Teachers have thousands of people who remember them for the rest of their lives. † It is so very true†¦ I now invite Harshit to come forward and convey all r special feelings to r dear teachers†¦ 5) Snehal (Video) Rightly said Harshit.. This reminds me of a little story I read back at school†¦ What Do Teachers Make? The dinner guests were sitting around the table discussing life. One man, a CEO, decided to explain the problem with education. He argued, Whats a kid going to learn from someone who decided his best option in life was to become a teacher? He reminded the other dinner guests what they say about teachers Those who can, do. Those who cant, teach. To stress his point he said to another guest; Youre a teacher, Susan. Be honest. What do you make? Susan, who had a reputation for honesty and frankness replied, You want to know what I make? I make kids work harder than they ever thought they could. I make a C+ feel like the winner of the Congressional Medal of Honor. I make kids sit through 40 minutes of study hall in absolute silence. You want to know what I make? I make kids wonder. I make them question I make them criticize. I make them apologize and mean it. I make them write and read I make them show all their work in math and perfect their final drafts in English. I make them understand that if you have the brains, and follow your heart, and if someone ever tries to judge you by what you make, must pay no attention because they just didnt learn. Susan paused and then continued. You want to know what I make? I MAKE U I MAKE A DIFFERENCE Here we now present a small video to reach out r hearts to one n all†¦ 6) Ratna: (Leela Rani Mam speech) I often wonder about teachers who educated famous people such as Einstein, Abraham Lincoln, and the like. Were these teachers specially qualified to inspire their students to achieve fame and success? Or were these teachers just plain lucky to have exceptionally talented students? Do some teachers have the rare quality of turning dust into gold? The answer may not be easy to find†¦ I would now request r respected Leela Rani Mam to please come forward and share few words of advice with us 7) Snehal (Shruti) As we move towards the end of today’s function, and before we proceed to d cake-cutting and snacks session, I would request Shruti to come forward are convey d vote of thanks on behalf of the MBA batch of 2012-14. 8) cake-cutting Snehal: I would take the pleasure of inviting all the faculty members to come forward for the cake cutting†¦ 9) Snacks (Ratna). Someone once said, Teachers dont impact for a year, but for a lifetime. A teacher can make a lasting impression on your mind. This influence persists beyond school, college and university, and becomes the beacon of light, guiding us through the journey of life. Good teachers play the role of a parent, providing encouragement, inspiration, and invaluable guidance†¦. We now bid a good-bye to this memorable evening and hope to create many such during r stay at BITS. We once again thank you all for being a part of this event and thereby appreciating r efforts†¦ Thank You†¦

Research Plan Essay Example for Free

Research Plan Essay Background of the Study Solid waste management is increasingly seen as a major issue in the country due to high rates of urbanization and increasing per capita solid waste generation with greater affluence (Petnamsin, et al., 2000). A major component of solid waste is resin based plastic. Plastics posses many properties such as water resistance and long life, that makes them perfect candidates for packaging. Unfortunately, the properties that make this product suitable for packaging also are the major cause of the environmental problems related to packaging. Given the wide use of plastics, the magnitude of the environmental problem is large and long terms. The choices for dealing with this waste are limited as incineration of plastic polymers invariably results in the generation of toxic emissions (Srorith, et al., 2000). The only visible solution is to bury the material in landfills. However, this approach is also limited because of the resistant nature of plastic to biological degradation. Jackfruit Artocarpus heterophyllus Lam. is a popular fruit-crop that is widely grown in tropical areas. Often, its seeds are discarded because of the preferred well-flavored yellow sweet bulb for consumption. The seeds have high carbohydrate and protein content, hence, an abundant source of starch (Kurian, 2010). Starch is identified as a key natural product for the production of biodegradable plastic (Pranamuda, et al., 2006). Based on the above information, the researchers decided to do research work on starch-based biodegradable plastic from jackfruit seeds. Henceforth, there is a need to establish the additive property of starch from jackfruit seeds as scientific basis for its use in the production of biodegradable plastic. Objectives of the Study The study will aim to find out if jackfruit Artocarpus heterophyllus Lam.  seeds can be a main component in the production of biodegradable plastic. Specifically, the study will 1. determine the efficacy of starch from jackfruit A.heterophyllus Lam. seeds at varying concentrations as additives in the production of biodegradable plastic. 2. compare the mechanical properties between the produced biodegradable plastic from starch of jackfruit A.heterophyllus Lam. seeds, and commercially prepared plastic, polyethylene in terms of tensile strength, flammability, soil biodegradability and air test. 3. compare the effects of acids and bases and organic solvents between produced biodegradable plastic from starch of jackfruit seeds and commercially prepared plastic, polyethylene. Hypotheses of the Study The following hypotheses will be put forward: 1. There is no significant difference in the efficacy of starch from jackfruit seeds at varying concentrations in the production of biodegradable plastic. 2. There is no significant difference on the mechanical properties between the produced biodegradable plastic from starch ofjackfruit seeds and commercially prepared plastic, polyethylene in terms of tensile strength, flammability, soil biodegradability and air test. 3. There is no significant difference on the effects of acids and bases and organic solvents between produced biodegradable plastic from starch of jackfruit seeds and commercially prepared plastic polyethylene. Significance of the Study The results of the study would be beneficial and helpful to the manufacturing plastic industries because it would relieve negative effects of overproducing plastics. By changing its raw materials and components, commercial plastic may be improved so that it would become biodegradable while retaining its good quality. Moreover,this component from starch of jackfruit seeds would help in the natural decomposition of plastic raw materials. Thus, a convenient way of minimizing waste management problem in the country, more so, the high demand for plastics would give the world the hazard of garbage problem, therefore, utilizing starch from jackfruit seeds as component in the production of biodegradable plastics would be the relative answer. Scope and Limitations of the Study The study will focus only on the starch-based biodegradable plastic from jackfruitA.heterophyllus Lam. seeds. It will be conducted at the Physics/Chemistry Laboratory of Antique National School, San Jose de Buenavista, Antique from July 15, 2011 to September 30, 2011. The variables to be evaluated will be the effect of starch from jackfruit seeds at varying concentrations for the production of biodegradable plastic; the mechanical properties between the produced biodegradable plastic from starch of jackfruit seeds and commercially prepared plastic, polyethylene in terms of tensile strength, flammability, soil biodegradability and air test;the effects of acids and bases and organic solvents between the produced biodegradable plastic from the starch of jackfruit seeds and commercially prepared plastic, polyethylene. Analysis of Variance (ANOVA) and Duncan Multiple Range Test (DMRT) will be used as statistical tools to identify the significant differences among treatment means and their interactions at 0.01 and 0.05 levels of significance, respectively. Definition of Terms Biodegradable.A substance or property of the produce plastic in the study that can be broken down into simpler substances by the activities of living organisms for decomposition.  Plastic. An end product obtained mainly as a result of the study using starch from jackfruit seeds as main component mixing with other components for biodegradable formation. Starch. A complex carbohydrate extracted from jackfruit seeds and used in the study for the production of biodegradable plastic. Polyvinyl Alcohol. An odorless, colorless, tasteless, thermoplastic synthetic resin used in the study that is soluble in water and insoluble in common organic solvents.  Glycerol. A simplest trihydric and commonly called glycerin in commercial  form that is used in the study for the production of biodegradable plastic. CHAPTER 2 REVIEW OF RELATED LITERATURE After cutting talahib pulps into very small pieces, they were combined with different chemicals such as polyvinyl alcohol, sodium hydroxide in aqueous solution, glue, and glycerol to produce biodegradable plastics with different amounts of talahib pulp. (Valdez, 2009). A study determined the effectiveness of cassava starch as component of biodegradable plastic. Results confirmed that cassava starch is ideal as tests proved its worth (Romero, 2007).  It was known that starch-based packaging materials are produced from extrusion or compression technology and have been developed as a substitute for polystyrene in producing loose-filters and other expanded items. The type of starch and synthetic polymer as well as their relative proportions in the blends may influence the properties of the resulting plastics (Sriroth and Sangseethong, 2003). Some physicochemical and rheological properties of jackfruit seed flour and starch, isolated from the flour were investigated. The flour had good capacities for water absorption and oil absorption. Flour from jackfruit seed was prepared by dry milling. It is high in protein and carbohydrate contents. The flour has good water and oil absorption abilities (Tulyathan, 2002). The range of possible applications for starch plastics is restricted by their sensitivity tomoisture and water contact and high water vapour permeability. The biodegradability of starch plastics largely depends on the biodegradability of the copolymer. High copolymer content can adversely affect biodegradability due to the complex interaction of starch and polyester at the molecular level (DegliInnocentiBastioli, 2002). Starch is unique among carbohydrates because it occurs naturally as discrete granules. This is because the short branched amylopectin chains are able to form helical structures whichcrystallize. Starch granules exhibit  hydrophilic properties and strong inter-molecular association via hydrogen bonding due to the hydroxyl groups on the granule surface (Daniel et al., 2000). Jackfruit Artocarpus heterophyllus Lam. is a popular fruit-crop that is widely grown in the Philippines and other tropical areas. The ripe fruit contains well-flavored yellow sweet bulbs which are consumed fresh or processed into canned products and seeds embedded in the bulb. Seeds make up around 10-15% of the total fruit weight and have high carbohydrate and protein content and are normally discarded or steamed and eaten as a snack or used in some local dishes. As fresh seeds cannot be kept for a long time, using them as source of starch is advisable (Bobbio et al 1978). Based on the above review of related literature, there is a need to conduct a study on starch-based biodegradable plastic from jackfruit Artocarpus heterophyllus Lam. seeds and because in all studies, nothing has been mentioned about jackfruit seeds as component of biodegradable plastics. CHAPTER 3 MATERIALS AND METHODS The flow of processes on starch-based biodegradable plastic from jackfruit Artocarpus heterophyllus Lam. seeds is shown in Figure 1. Collection and Preparation of Research Materials, Tools and Equipment The researchers will collect three (3) kilograms of jackfruit seeds from the source for two (2) days before the conduct of the study. These will be brought to the Physics/Chemistry Laboratory of Antique National School, San Jose de Buenavista, Antique. Technically grade ethanol, hydrochloric acid, acetic acid and sodium hydroxide, ammonia, distilled water, chlorine, polyvinyl alcohol, epoxydized soy bean oil, and glycerol will be obtained from chemworks, Inc.Jaro, Iloilo City prior to the conduct of the study. The other materials and equipment needed will be mortar and pestle, grinder, beakers, alcohol lamp, rolling pin, aluminum foil, stirring rod, molders, spring balance, double beam balance, tray, plastic cups, graduated cylinder, stopwatch, and hot plate. Research Procedure/ Experimental Design Three (3) kilograms of jackfruit seeds will be rinsed and washed in running water and will be air-dried for twenty-four (24) hours at room temperature. After air-drying, the seeds will be peeled manually. Then the seeds will be cut into smaller pieces and ground using an electric grinder. The ground jackfruit seeds will be added with water following the ratio 1:2, one (1) liter of distilled water to two (2) kilograms of ground jackfruit seeds. The mixtures will be placed inside the beaker for decantation for three (3) hours. After decantation, the supernatant will be discarded and the settling material will be collected and placed in an evaporating dish for the starch sediments to settle. This will be sun-dried for five (5) hours to let the water evaporate completely. After the evaporation process, the collected starch sediments will be ground using mortar and pestle until it will turn into powdered form. The produced starch will be weighed and placed in a sterilized container ready for experimentation. Measured amount of the water and jackfruit starch based on different treatments will be mixed and boiled using a hot plate at eighty (80(C) degrees Celsius until it will form into a sticky paste. After removing the starch-water mixture from the hot plate, the rest of the materials will be added such as polyvinyl alcohol, epoxydized soya bean oil, and glycerol. After mixing all the materials, the mixture will be heated again using a hot plate at a temperature of one hundred eighteen to one hundred twenty (118-120(C) degrees Celsius for seven (7) minutes. Then it will pass through a rolling pin and transferred to containers for sun-drying process until the plastic will be formed. The plastic will be cut into strips (3 cm wide by 5 cm long) for mechanical property, effects of acid and base, and organic solvents tests, respectively. The experiment will use five (5) treatments with three (3) replicates each. The duration of the experimental activities will be seventy-eight (78) days that will begin on July 15, 2011 and will end on September 30, 2011. The five (5) treatments that will be used in the study are as follows. Treatment A = 100 grams starch + 100 grams water + 100 grams polyvinyl alcohol + 2.5 grams epoxydized soya bean oil +10 grams glycerin Treatment B = 75 grams starch + 100 grams water + 100 grams polyvinyl alcohol + 2.5 grams epoxydized soya bean oil +10 grams glycerin Treatment C = 50 grams starch + 100 grams water + 100 grams polyvinyl alcohol + 2.5 grams epoxydized soya bean oil +10 grams glycerin Treatment D = 25 grams starch + 100 grams water + 100 grams polyvinyl alcohol + 2.5 grams epoxydized soya bean oil +10 grams glycerin Treatment E – Control – Commercial plastic (polyethylene) Gathering of Data The cut samples of the produced biodegradable plastic will be subjected to the following tests: Flammability Test. The strips of the produced biodegradable plastic and commercial plastic with the same dimensions will be completely burned using alcohol lamp and the burning time will be noted. Soil Biodegradability Test. The plastic strips will be stapled to a piece of cardboard and will be buried in a can of soil. The strips will be unearthed after a week and the final dimension will be recorded. Tensile Strength Test. The plastic strips will be hooked to a spring balance and will be pulled until they will tear apart. The reading of the balance when the plastic strips will break will be recorded. Effects of Strong and Weak Acids and Strong and Weak Bases.The plastic strips will be immersed in concentrated strong/weak acids and strong/weak bases for thirty (30) minutes. Changes in length, width, and appearance will be noted. Organic Solvent Tests. The plastic strips will be immersed in a bottle of  chlorinated water/ethanol. The bottle will be sealed so as to isolate its contents from the external environment. After a week, their final dimensions will be noted.

Sunday, July 21, 2019

Cytochrome P450 and Breast Cancer

Cytochrome P450 and Breast Cancer Cytochrome P450 The cytochrome P450 (CYP) enzymes are a superfamily of haem-containing mono-oxygenases involved in the oxidative metabolism of a wide range of xenobiotics and endogenous compounds including steroids in the body.(40, 41) These membrane-bound enzymes are found primarily in the liver, sited in the smooth endoplasmic reticulum (SER) of hepatocytes.(42) CYPs are also found, to a lower extent, in extra-hepatic tissues such as the small intestine, kidney and lung where they carry out enzymatic biotransformation of foreign chemicals.(43) In human liver, three main CYP families (CYP1, CYP2 and CYP3) are heavily involved in drug metabolism.(44) Phase 1 metabolism reactions such as oxidation, reduction and hydrolysis of substrates introduce functional groups into drug molecules. The intermediate metabolites then enter Phase 2 reaction which involves conjugation to produce inactive polar metabolites for elimination from the body.(30) Most P450 metabolisms deactivate substrates to form inactive intermediates for elimination; paradoxically, CYPs can convert substrates into active intermediates which contribute to cellular toxicity or carcinogenicity.(30, 43) + Figure 11: The microsomal monooxygenase P450 system. Cytochrome P450 incorporates one atom of oxygen to the substrate (RH), forming a hydroxylated product (ROH); and incorporates another atom of oxygen to form a water molecule. NADPH serves as a coenzyme in the system. The hydroxylated product can then undergo Phase 2 reactions to produce conjugates which are catalysed by a variety of enzymes such as gluthathione transferases.(43) Cytochrome P450 and Breast Cancer CYPs are involved in the metabolism of a wide range of substrates including carcinogens and anticancer drugs.(43) CYPs can convert anticancer drugs into inactive metabolites; or activate mitogenic compounds such as the oestradiol metabolite 4-hydroxyestradiol.(45) It was established that metabolism of the carcinogen benzopyrene by CYPs may generate products which can cause specific mutation in the p53 gene and initiate cancer.(46) The microsomal monooxygenase P450 system (MMO) generates ROS which, at high levels, can induce cellular oxidative stress which affects cancer cell proliferation.(47, 48) Expression of individual CYPs were observed in different types of human cancers including breast cancer.(43) However the knowledge on the role of CYPs in cancer cells is limited. This has attracted increasing interest of experimentalists in the investigation of the effect of CYP-mediated metabolism in cancer cells. Over the years, overexpression of CYP1A1 and CYP1B1 are the most profound findings in the field of pharmaco-oncology.(44) CYP1A1 catalyses the metabolism of oestradiol to inactive 2-hydroxyestradiol for excretion from the body.(41, 49) In contrast, CYP1B1 mediates conversion of oestradiol to 4-hydroxyestradiol which is capable of producing ROS and contributes to breast carcinogenesis.(41, 49) Previous study has reported that oestradiol can regulate CYP1B1 expression in MCF-7 cells through ER-mediated pathway.(41) Another study treated MCF-7 cells with aryl hydrocarbon receptor agonist which induces P450 enzymes to catalyse 4-hydroxylation of 17ÃŽ ²-estradiol.(50) Higher CYP1B1 mRNA levels and increased hydroxylation activity of 17ÃŽ ²-estradiol were observed in breast tumours. (50) This correlates with another study which had shown that CYP1B1 protein was absent in normal breast tissue.(51) Murray et al. had identified the presence of CYP1A and CYP3A in 40% and 22% of the breast tumours respectively.(52) Another P450 subfamily CYP2C was also reported to be present in both normal and breast tumour tissues at similar levels.(53) These evidences further support the hypothesis that expression of individual CYPs in breast cancer cells might play a role in breast tumourigenesis. If the hypothesis is confirmed to be true, the levels of individual CYPs in breast tumour can become a good marker in providing diagnostic and therapeutic strategies in breast cancer treatment. CYP2C8 Figure 12: The structure of CYP2C8, a haemoprotein from the cytochrome P450 superfamily. Figure adapted from reference (54). CYP2C8 is a member of the CYP2C subfamily which accounts for 7% of the total microsomal CYP content.(55) CYP2C8 mediates Phase 1 oxidative metabolism of about 5% of drugs in the liver.(55) Sited mainly in the endoplasmic reticulum of hepatocytes, CYP2C8 mRNA was also detected in extra-hepatic sites such as the kidney, brain, uterus and mammary gland.(56) In a study, 10 breast cancer tissue samples were analysed using specific primers for RT- PCR for the expression of CYP2C8.(57) Interestingly, CYP2C8 mRNA was detected in all the samples analysed.(57) Another study has detected CYP2C8 mRNA in breast cancer cells and CYP2C8 knockdown suppressed the growth of breast cancer cell lines MCF-7, T47D and MDA-MB-231.(58) Anti-cancer drug Paclitaxel and carcinogen benzopyrene are the main substrates of CYP2C8 in enzymatic metabolisms.(43) CYP2C8 primarily catalyses 6ÃŽ ±-hydroxylation of Paclitaxel, a mitotic inhibitor used in malignant tumour, into inactive metabolite for elimination.(59, 60) Results from several studies had shown that single-nucleotide polymorphisms (SNPs) in CYP2C8 gene, especially the CYP2C8*3 variant allele which is more common in Caucasians, results in alteration in CYP2C8 enzymatic activity.(61, 62) Dai et al. had reported that subjects homozygous for CYP2C8*3 had decreased 6ÃŽ ±-hydroxylation Paclitaxel metabolism compared to subjects with wild-type CYP2C8 gene.(62) As a result, although more likely to achieve therapeutic response from Paclitaxel treatment, breast cancer patients who are CYP2C8*3 carriers have a significant increased risk of neuropathy due to the narrow therapeutic window of Paclitaxel.(60, 61, 63) Besides, it was also reported that CYP2C8*3 variant caused defective metabolism of an endogenous CYP2C8 substrate, arachidonic acid, into epoxyeicosatrienoic acids which promote invasion in vitro and angiogenesis in vivo.(62, 64) In mice, overexpression of CYP epoxygenase in the metabolism of arachidonic acid had resulted in metastasis of MDA-MB-231 human breast cancer cells to the lungs associated with angiogenesis.(65) In another study involving 652 breast cancer patients in Southern Sweden, CYP2C8 polymorphism was studied against early breast cancer-related events to investigate the impact of polymorphism on breast cancer-free survival after diagnosis. (64)The result had shown that CYP2C8*3 variant resulted in shorter disease free survival in 297 ER-positive patients with invasive tumours treated with Tamoxifen, probably due to the role of CYP2C8 in drug metabolism.(64) In addition, researchers also found out that CYP2C8*3 carriers with breast tumour larger than 20mm had more than twofold higher risk of lymph node involvement.(64) Despite studies had detected the expression of CYP2C8 in breast cancer cells, its role in breast cancer is still not widely known. It has been hypothesised that overexpression of CYP2C8 may influence proliferation of breast cancer cells due to its role to generate reactive oxygen species (ROS) as a by-product of the process of breast cancer drugs’ metabolism. Furthermore, CYP2C8 polymorphism might result in inter-individual variation in tumour progression and therapeutic response to anticancer treatments. The expression levels of CYP2C8 in breast tumours might therefore be a good target in designing new anticancer drugs. Quercetin: The CYP2C8 Inhibitor Figure 13: The chemical structure of the CYP2C8 inhibitor Quercetin and its derivatives. Figure adapted from (66). Quercetin is a flavonoid found in a variety of polyphenols such as fruits, vegetables and plants.(67) As a competitive inhibitor of CYP2C8, Quercetin inhibits the 6ÃŽ ±-hydroxylation of taxol catalysed by CYP2C8.(68) Quercetin was reported to inhibit cell proliferation of several human cancers such as leukaemia, gastric carcinoma and breast carcinoma.(68) Currently Quercetin is under Phase 1 clinical trial for anticancer treatment. (68) Quercetin showed a dose-dependent inhibition on cell growth of ER-positive MCF-7 breast carcinoma which could be reversed by removal of Quercetin from culture medium or by addition of 17ÃŽ ²-estradiol to the cells treated with Quercetin.(69) In another recent study, researchers had shown that Quercetin induces cell cycle arrest and apoptosis in a time and concentration-dependent manner in cell line MCF-7 (refer Figure 15).(67) The results had suggested that Quercetin might be a promising anticancer drug although its exact mechanism on inhibiting cell proliferation is not fully understood. Quercetin’s effect on CYP2C8 activity and ROS production might explain its role in inhibiting carcinogenesis. Table 1: The effect of Quercetin on the cell cycle and apoptosis of MCF-7 cells shown in a study carried out by Deng et al. Quercetin inhibition on cell growth activity was dose-dependent. The concentration of Quercetin was also found to be positively correlated with apoptosis rate of the cells.(67) Reactive Oxygen Species (ROS) Reactive oxygen species are the by-products of normal respiration process in the mitochondria.(70, 71) Apart from mitochondria, ROS is also produced from biochemical reactions that use oxygen molecules, such as the P450 monooxygenase system (MMO) in the endoplasmic reticulum.(70) Free radical ROS are highly reactive oxygen molecules which carrying an unpaired electron in their outer shell and seek for another electron in order to become stable.(72) Some examples of ROS include superoxides, peroxides and hydroxyl radicals.(72) A recent study had demonstrated increased intracellular ROS levels in MCF-7 and MDA-MB-231 cells following overexpression with CYP2E1.(48) This suggests that an alteration in the levels of the P450 enzymes might play a role in the production of intracellular ROS hence proliferation of cancer cells. Figure 14: The monooxygenase P450 cycle. Binding of substrate (RH) leads to conformational change which favours the reduction of ferric iron (Fe3+) in P450. An addition of single electron from NADPH to P450 via NADPH-P450 reductase converts Fe3+ to ferrous iron (Fe2+). An oxygen molecule binds to the Fe2+RH to form the Fe2+O2.RH complex. Addition of a second electron from either the NADPH-P450 reductase or the cytochrome b5 and a proton form a Fe2+OOH.RH peroxide complex. The complex then accepts a second proton which leads to cleavage of the Fe2+OOH.RH complex into ferric oxene substrate complex, (FeO) 3+.RH and a water molecule. The ferric oxene extracts a hydrogen atom from the substrate to yield a pair of radicals Rà ¢-  and Fe2+OHà ¢- . The last step involves binding of Rà ¢-  with the hydroxyl radical OHà ¢-  to generate the hydroxylated drug (ROH) to be realised from the complex. The P450 is then regenerated in its initial state.(73) Diagram adapted from refere nce (74). At low levels, ROS maintains normal physiological functions such as modulation of signal transduction pathways and cell proliferation.(75) However high levels of ROS can cause cellular toxicity, lipid peroxidation, DNA damage, cell proliferation arrest and apoptosis.(76-78). The antioxidant defence systems in cells comprise of a group of antioxidant compounds such as Vitamin E, superoxide dismutase, catalase and glutathione peroxidase which function to cope with the high intracellular ROS levels. However, an excessive production of ROS or a lack of antioxidants can disrupt the balance and result in oxidative stress. (72) Intracellular oxidative stress can cause DNA damage, endoplasmic reticulum (ER) stress and apoptosis.(77, 79) Oxidative stress caused by elevated levels of ROS is implicated in cancer as it is associated with alteration in DNA sequence which leads to activation of proto-oncogenes or inactivation of tumour suppression genes.(77) Such mutations may initiate cancer and provide malignant cells with advantageous characteristics as described in Figure 1 ‘Hallmarks of cancer’ to facilitate growth and metastasis.(25, 77, 80) Increased DNA base damage resulted from hydroxyl radical attack has been reported in inflammatory breast cancer.(81) Figure 15: High levels of ROS in cell results in DNA damage, misfolded proteins, lipid peroxidation, mitochondrial dysfunction and apoptosis. The antioxidant defence systems counteract with the excessive production of ROS. An imbalance between ROS generation and antioxidant action can result in oxidative stress and threaten cell survival. Diagram adapted from reference(82).        

Saturday, July 20, 2019

Herbal Dietary Supplements :: Diet Supplement Weight Loss Gain Research Paper

Herbal Dietary Supplements Fit America Fit America touts itself as the very best and most practical 100% Natural system of weight loss that helps an individual lose weight without dieting. Fit America is a natural weight control that is composed of 13 herbs and minerals that supposedly "help suppress appetite, regulate the bowels and kidneys, and stimulates the metabolism so the body uses the foods consumed more efficiently." The Fit America program requires a high protein, low carbohydrate diet. Fit America promises that an individual can expect to lose up to 10 to 18 pounds per month with a proper balance of food and water consumption. These herbal supplements include astragalus, bitter orange, cascara sagrada, fo-ti, gingko, english hawthorn, henna, licorice root, ma huang, and valerian root. It is recommended that individuals who utilize the Fit America program begin by taking one gray colored herbal capsule twice a day and one peach colored herbal capsule once a day. The Fit America program then encourage s the individual to gradually increase their dosage of grey colored capsules but to take no more than eight in one day1. For a 7 - 10 day starter kit of Fit America, the price is $29.95. For a 45 day supply, the cost is $139.00. I will attempt to review the safety of these herbs and their effects on the human body. Herbal Regulations When a pharmaceutical company desires to market a prescription drug, they must meet certain procedures and standards established by the Food and Drug Administration (FDA). These procedures can last many years and incur hundreds of millions of dollars of cost for the pharmaceutical company. Before a drug can be marketed, it must first be patented and then pass three phases of clinical investigation. In Phase I, the drug is tested by giving a small amount of it to a limited number of people. At this stage, the researchers are looking for the pharmacological effects on the body such as side effects. In Phase II, individuals who have the condition that the drug is supposed to treat are tested. Approximately 100 people are tested in this phase. If Phase II shows signs of promise, then clinical investigations move into Phase III.

Friday, July 19, 2019

We Need Automatic Voter Registration Now :: Politics Political Essays

We Need Automatic Voter Registration Now    Political participation should not plummet in the new millennium. Young people should automatically become registered on their eighteenth birthday. With all of the new technology our now it should be able to be done. All babies are given social security numbers shortly after birth. From this procedure every individual should be registered to vote on their eighteenth birthday.    Every young person enrolled in high school should be required to take and pass a current government class that teaches the student about the current government laws and political offices and who holds the current positions. If this is done no one should have the excuse not to vote because they don't know who to vote for or who the candidates are. Keeping the young informed and involved in politics and the politicians and their views can only help in getting them to vote and stay involved.    The voting age should not be lower than 18 years of age. Voting is an earned privilege and is given to mature individuals who want to make a difference in their lives. To vote for the candidate that will best serve the office in which they are elected is what young people should look forward to. Every eligible person should want to participate in making a difference in the country in which they live. Everyone young or not should be provided with: all of the information on all political offices that are to be voted on; what the person elected to the office is responsible for and the qualifications it takes to obtain the position; and, what the position is supposed to accomplish for the well being of the citizens.    Keeping lines of communication open for everyone is another way of helping voters to encourage voters to exercise their rights to vote. Keeping the ballots simple and uncomplicated also is great help to the young and elderly. Making sure the voting day and the voting hours are suitable to all working people with odd shifts easy to get to vote.    The absentee ballots that are available are also a great idea for people who can not get to the polls on Election Day. Keeping things simple and uncomplicated are ways to help young people to use their rights to vote and make a difference in this political world.

The Mistreatment of Women in the Works of Zora Neale Hurston :: Biography Biographies Essays

The Mistreatment of Women in the Works of Zora Neale Hurston Society is suffering from a number of serious social problems related to women, and to the interaction between the two sexes. Male domination and patriarchy have been under challenge by feminists and the women's movement. The economic, social and political subjection of women around the world, the violence brought against women and their confinement has been brought to the forefront in recent years. Zora Neale Hurston's stories speak out against the uncivil and unjust treatment of women especially in their marriages. Hurston's stories reveal the disturbing situation for women about mistreatment abuse in the 1930s, when speaking out was unheard of. This was the time period for the setting of Hurston's stories, and her stories reflect violence against women that occurred during that era. "Zora Neale Hurston's works are brilliant glimpses into the mind of a woman who lived life for what it was, who wanted nothing more then to have"...a busy life, a just mind and timely death." "She lived as she wrote, to the fullest, she wasn't just a writer, but also an anthropologist who brought to the light the folklore, and culture of nations that before there had been little study of. She brought new, exciting views of the world through her poetic words, and is a shining example of what it is to be a woman. Intelligent, driven, and confidant" (Walker 8). At only thirteen years old Hurston was thrown out of her father's house because her stepmother didn't approve of her or her siblings. At an early age Huston knew about struggling and making a way for herself (Ford 7-9). In Zora Neale Hurston's autobiography she said, "There is something about poverty that smells like death. Dead dreams dropping off the heart like leaves in a dry season and rotting around the feet, impulses smothered too long in the fetid air of underground caves. The soul lived in a sickly air. People can be slave ships in shoes (Hurston 37). Hurston was mistreated as a child, and in her story "Drenched in Light" it reveals some of her background of child abandonment. She also focused on women's rights and fights in marriages.